The Effect of Local Application of Magnesium Oxide Powder on the Blood Parameters During Nerve Regeneration of Injured Sciatic Nerve in Rat

Authors

  • Helal Montaser
  • Hussein Aseel

DOI:

https://doi.org/10.37506/ijfmt.v16i1.18065

Keywords:

Sciatic nerve injury, microparticles, nanoparticles, sciatic nerve injury, magnesium level and NGF in rats.

Abstract

Peripheral nerves injuries are very common defects in animals which may lead to loss of sensory and
motor functions of the nerve. These defects are highly corrected using nanotechnology. This study
aimed to find out the effect of applying local application of magnesium Nano- and Microparticles on
the level of magnesium and rat nerve group factor in rat during the process of nerve regeneration. This
study included sixty adult male apparently healthy Wistar rats had bodyweight average (M±SD: 230
± 20) gram. Random division to three group was done as: Controlgroup (CG), Nanogroup (NG) and
Microgroup (MG) of (n=20) each after transecting the sciatic nerve and instant proximal and distal end
of the sciatic nerve suturing. First group the (Controlgroup) which had no interferences after suturing;
the second group (Nanogroup) had a local application of nanoparticles powder of MgO on sutured site
in addition to third group (Microgroup) had a local application of microparticles powder of MgO on
the sutured site. The results showed that a significant and continuous increase of rat growth factor to be
seen in Nanogroup and Microgroup however, Microgroup had the highest level to the end of the study,
while no significant correlation between the three groups and level of Mg during the study was seen. It
is concluded that MgO forms of Micro and Nano particles have a positive effect on nerve regeneration
which can be determined by significant increase of NGF in Microgroup then Nanogroup but not in
Controlgroup. In addition to that using low dose of local application of Nano and Microparticle has no
systemic toxicity on body.

Author Biographies

  • Helal Montaser

    Scholar Researcher Department of Surgery and Obstetrics and Medicine, College of Veterinary Medicine/
    University of Tikrit, Iraq

  • Hussein Aseel

    Scholar Researcher Department of Veterinary Surgery and Obstetrics, College
    of Veterinary Medicine/University of Baghdad, Iraq

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Published

2021-11-30

How to Cite

The Effect of Local Application of Magnesium Oxide Powder on the Blood Parameters During Nerve Regeneration of Injured Sciatic Nerve in Rat. (2021). Indian Journal of Forensic Medicine & Toxicology, 16(1), 1759-1765. https://doi.org/10.37506/ijfmt.v16i1.18065