Single-dose Acute Toxicity of 4-F-MDMB-BUTINACA Designer Cannabis Drug: LD50 and Histological Changes in Mice

Authors

  • Elkhatim H. Abdelgadir ElAmin
  • Renad H. F. Albloi
  • Abdulsallam Bakdash
  • Sachil Kumar

DOI:

https://doi.org/10.37506/ijfmt.v16i3.18271

Keywords:

Forensic Toxicology; 4-F-MDMB-BUTINACA; Synthetic Cannabinoid; LD50; Histopathology; Mice.

Abstract

The purpose of this research was to evaluate the single-dose toxicity of 4-F-MDMB-BUTINACA in Swiss albino
mice using histopathological analysis of liver and kidney specimens.
The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg body
weight of 4-F-MDMB-BUTINACA) for 24 hours. At the end of the treatment, blood samples had been drawn, and
renal and hepatic tissues have been excised from the experimental mice groups for histological examinations.
The results revealed that dose-dependent treatment with 4-F-MDMB-BUTINACA causes mild tremor clinical
signs with low doses and photophobia (sensitivity to light) and even cessation of breathing as a potential cause of
death with high doses in treated mice.
The LD50 value of 4-F-MDMB-BUTINACA was 32.60 mg/kg, which is considered as a chemical compound of low
toxicity. Histological studies confirmed that liver and kidney toxicities have been manifested in the findings of
congestion, necrosis, inflammation, and bleeding within the liver and to lesser extent in the kidneys.

Author Biographies

Elkhatim H. Abdelgadir ElAmin

Assistant Professor,Department of Forensic Sciences, College of Criminal Justice, Naif
Arab University for Security Sciences, Riyadh-Kingdom of Saudi Arabia.

Renad H. F. Albloi

Master Student, Department of Forensic Sciences, College of Criminal Justice, Naif
Arab University for Security Sciences, Riyadh-Kingdom of Saudi Arabia.

Abdulsallam Bakdash

 Assistant Professor, Department of Forensic Sciences, College of Criminal Justice,
Naif Arab University for Security Sciences, Riyadh-Kingdom of Saudi Arabia.

Sachil Kumar

Assistant Professor, Department of Forensic Sciences, College of Criminal Justice,
Naif Arab University for Security Sciences, Riyadh-Kingdom of Saudi Arabia.

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Published

2022-07-04

How to Cite

Elkhatim H. Abdelgadir ElAmin, Renad H. F. Albloi, Abdulsallam Bakdash, & Sachil Kumar. (2022). Single-dose Acute Toxicity of 4-F-MDMB-BUTINACA Designer Cannabis Drug: LD50 and Histological Changes in Mice. Indian Journal of Forensic Medicine & Toxicology, 16(3), 145–152. https://doi.org/10.37506/ijfmt.v16i3.18271