The Correlation between Insulin Resistance and Urotensin II in Patients with Gestational Diabetes Mellitus
Keywords:Diabetes; insulin resistance; urotensin II.
Gestational diabetes mellitus is glucose intolerance of varying degree with onset or first detection duringpregnancy,
it can causelong and short term morbidities in both the mother and the child, such as shoulder dystocia,
preeclampsia, and high blood pressure. The most powerful endogenous vasoconstrictor peptide, urotensin II, and
its receptor are involved in the etiology of gestational diabetes mellitus.
Aim of the study: The study’s goal was to see if there is a link between Urotensin II levels and insulin resistance
in pregnant women with gestational diabetes.
Patients and method: A case-control study that was conducted in obstetrics and gynecology department at
Baghdad Teaching hospital from the first of January 2019 to the end of December 2019. A sample of 80 pregnant
women participated in the study fulfilling inclusion criteria. 40 of them diagnosed with gestational diabetes
mellitus by (2 hours 75 gm. Oral glucose tolerance test) and 40 women as control group.
Results: The mean age of the gestational diabetes mellitus group was 29.8±6.9 years and control was 29.7±6.6
years with no significant differences. The study showed highly significant increase infasting Insulin, fasting blood
glucose, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), of the GDM group than that in the
group without disease. Significant difference was found regarding high-sensitivity C-reactive protein hs-CRP
(p=0.004). The level of Urotensin II in subjects with gestational diabetes was (109±33.22) highly increased than that
in healthy subjects (78±22.6). There is a positive correlation between circulating Urotensin II levels with fasting
insulin, and HOMA-IR. While negative correlation found with fasting blood glucose.
Conclusion: The level of UII was found to be raised in gestational diabetes pregnant women
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