Clinical Course and Outcome of COVID-19 Patients in a Tertiary Care Hospital: A Retrospective Study
Keywords:Antiviral; Comorbidity; COVID-19; HRCT; Nasopharyngeal Swab; Negative Swab; Mortality; PCR antigen test.
Introduction: COVID-19 the deadly virus, was declared a pandemic by WHO in March, 2020 because of its
virulent nature. It has been a piece of work to understand the mechanism of action and the disease pathology of
the virus, due to its novel origin. The quality of healthcare is seen to be severely degrading during these times. The
two different types of COVID tests that are commonly available in the facility are RTPCR and Rapid Antigen Test
or RAT. These help to identify whether the person is infected with the virus or not. With the current management
being successful in majority of the cases, we should also consider strengthening the existing modalities.
Objective: To find the prevalence of COVID-19 patients and study their clinical course and outcome
Material and methods: Data regarding covid-19 patients was collected on basis of demographic profile by using
google foms questionnaire at Dr. D.Y. Patil Hospital, Navi Mumbai.
Results: A total of 500 patients were included in the present study with male preponderance with 61.4%. 99%
patients were tested COVID positive, 73.2% had a history of exposure to COVID patients, 80% had a positive travel
history, 99% lab tests were positive. 50.4% duration of the treatment lasted for 7-14 days. 67.6% were treated in
the wards, whereas, the remaining 32.4% were treated in the ICU. 19.6% patients required mechanical ventilator
support. 51% patients required oxygen therapy. 80.2% did not require intubation. All the patients were on
antibiotics, and majority of the patients, i.e. 99.8% were on immuno-boosters as well. Antivirals were administered
in 80.6%. 82.8% were discharged with a negative swab. Out of the 17.2% patients with positive swab, mortality was
seen in 6.2% patients. 3.4% patients were referred to different centers, while the treatment of the remaining 7.6%
patients was continued for a longer period of time.
Conclusion: A stepwise perspective of non-pharmaceutical interventions, screening and testing procedures,
implementation and compliance to distancing, hygiene measures and use of masks at airports, railway stations,
other public places with pragmatic testing and tracing are effective measures that can be implemented. Worldwide
numerous clinical trials are taking place for the treatment and prevention of COVID-19. Although, there is a rapid
comprehensive expansion in regard to COVID-19 and few agents appear to be promising, there are no definitely
proven effective therapies at this time. Evaluation of several agents by Scientists and researchers are progressive
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