The Prevalence and Success Factor of Ibuprofen and Paracetamol Administration for Neonates with Patent Ductus Arteriosus at RSUD Dr. Soetomo
Keywords:Patent Ductus Arteriosus; neonate; ductus arteriosus.
Background: Four thousand neonates with Persisten Ductus Arteriosus every year in Indonesia. There are two
treatment options to treat Persistent Ductus Arteriosus, they are surgery and pharmacological therapy. Ibuprofen
and paracetamol can be used as pharmacological therapy for Persistent Ductus Arteriosus with minimal side
Objective: To analyze the prevalence and success factors in giving ibuprofen and paracetamol in neonates with
persistent ductus arteriosus.
Method: This research is an observational analytic research with cross-sectional method. The determination of the
research sample uses a total sampling technique by taking all members of the population in accordance with the
conditionsfrom January, 2016 to March , 2020. Bivariate analysis was perform using the Spearman rank test with
95% confidence interval (α=0.05).
Result: From 51 samples that met the inclusion criterias, it was found that the most criterias were male (66.67%),
normal birth weight (60.78%), aterm (76.48%), moderate defect size before being administrated pharmacological
therapy (47.06%), pharmacological therapy using paracetamol (88.24%), atrial septal defect in the cardiac
comorbidities category (21.74%) and hyperbilirubinemia in the non-cardiac comorbidities category (13.04%). The
majority of lumen defects in neonates were closed completely after being administrated pharmacological therapy
(72.55%). Statistical test results of spearman rank showed that no significant relationship between birth weight
and pharmacological therapy in RSUD Dr. Soetomo. There was a significant relationship between gestation and
pharmacological therapy (p = 0.000; r = -0.495; r2 = 0.237, 95% CI). There was a significant relationship between the
size of the ductus arteriosus defect before therapy and pharmacological therapy (p = 0.001; r = -0.435; r2 = 0.211,
Conclusion: The success factors in administrating ibuprofen and paracetamol for neonates with persistent ductus
arteriosus in RSUD dr. Soetomo from January 1, 2016 to March 3, 2020 were affected by gestation period and size
of the ductus arteriosus defect prior to pharmacological therapy.
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