Allele Frequencies and Forensic Statistical Parameters for 21 Autosomal Short Tandem Repeats (STRs) loci in Northern Thai Population

Authors

  • Supakit Khacha-ananda
  • Yutti Amornlertwatana
  • Phatcharin Mahawong
  • Nitaya Khamkomkai

DOI:

https://doi.org/10.37506/ijfmt.v16i3.18310

Keywords:

short tandem repeats; northern Thai; allele frequencies; forensic genetic.

Abstract

Background: Although the genetic information of STRs has been established over the entire world, the different
characteristics between populations influenced the STRs information. FBI’s guideline recommended to expand
additional number of STRs loci to increase power of discrimination and exclusion. Unfortunately, the current
data of STRs in northern Thai population have not fully covered additional loci. The aim of this study is to obtain
accurate allele frequencies of STRs among northern Thai population.
Methods: The genetic profiles ofunrelated individuals were characterized by Investigator 24 plex Go kit. Allele
frequencies and forensic statistical parameters were calculated within GenoProof®3and Arlequin ver 3.5.2.2.
Results: The SE33 and TH01 loci represented largest and lowest number of different alleles, respectively. There
was no significant deviation from the Hardy–Weinberg equilibrium (HWE) after Bonferroni correction in all loci
(p=0.002). The SE33 locus showed the greatest PD and PE, whereas the TPOX represented the lowest PD and PE.
The studied population (northern Thai) appear to be most closely related to previously reported populations
containing of Chinese, Japanese, and Vietnamese based on allele frequency.
Conclusion: Our results recommended that current autosomal STRs data extended the application of STRs typing
in parentage analyses and human identification among the localized population in northern region of Thailand
due to highly informative polymorphic data.

Author Biographies

Supakit Khacha-ananda

Instructor, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai,
50200, Thailand

Instructor, Research Center in Bioresources for Agriculture, Industry and Medicine, Chiang
Mai University, Chiang Mai, Thailand

Yutti Amornlertwatana

Instructor, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai,
50200, Thailand

Phatcharin Mahawong

Medical Technologist, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Nitaya Khamkomkai

Scientist, Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

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Published

2022-07-04

How to Cite

Supakit Khacha-ananda, Yutti Amornlertwatana, Phatcharin Mahawong, & Nitaya Khamkomkai. (2022). Allele Frequencies and Forensic Statistical Parameters for 21 Autosomal Short Tandem Repeats (STRs) loci in Northern Thai Population. Indian Journal of Forensic Medicine & Toxicology, 16(3), 354–359. https://doi.org/10.37506/ijfmt.v16i3.18310