Assessment of Serum Ferritin, Folate, Vitamin B12, C-reactive Protein, D-dimer and Homocysteine in Patients with Severe and Critical Covid-19 Infection

Abstract

Background: Corona virus disease 2019 (COVID-19) pandemic need urgent measurement and correlation
of laboratory parameters in severe and non-severe cases. Serum ferritin, folic acid, vitamin B12, C-reactive
protein, D-dimer and homocysteine was measured in patients who were infected with COVID-19.
Aim of the Study : To evaluate the usefulness of serum ferritin, folate, B12, C-reactive protein, D-dimer and
homocysteine level as biomarkers for prediction of patients with severe and critical COVID-19 infection.
Subject, Material, Method: A cross sectional study was conducted at AL-Kindy hospital, Baghdad, Iraq
from October 2020 to December 2020. Serum ferritin, folate, Vitamin B12, C-reactive protein, homocysteine
and blood D-dimer were measured in 88 patients who suffered from COVID-19 infection, 50 cases with
severe infection and 38 with non-severe infection. The age range of patients between 20-59 years old.
Samples were collected from AL-Kindy hospital, Baghdad.
Result: Serum folic acid was significantly low in severe group than in non-severe group, while serum
ferritin, CRP and blood D-dimer were high in severe group than in non-severe group.
Conclusion: In this study, measurement of serum ferritin, CRP and blood D-dimer were important in follow
up of patients who infected with the novel virus as the level of them were higher in severe than in nonsevere
cases. Folic acid has role in determining the severity of COVID-19 infection bacause level was low
in patients with severe than non-severe infection.