The Development and Standardization of a Proctological Agent Based on Black Cumin (Nigella Sativa L.) Extract

Authors

  • Nigmatkhodjaev Akbarkhodja Bahodirkhodjaevich
  • Abdullabekova Viloyatkhon Nurullabekovna
  • Yunuskhodjaev Akhmatkhodja Nigmanovich
  • Iskandarova Shakhista Fekhruzovna

DOI:

https://doi.org/10.37506/ijfmt.v16i4.18610

Keywords:

: dry extract of Nigella sativa, suppositories, thymoquinone, anti-inflammatory activity

Abstract

Annotation. Nigella sativa L. (Ranunculaceae) is one of the promising plants that has a wide spectrum of
pharmacological activity. The black cumin is known to have been used for the treatment of cataracts, bronchial
asthma, cholelithiasis and urolithiasis, helminthic invasions, diabetes, hemorrhoids, and many other diseases.
The aim of this study is to develop and standardize a drug based on a dry extract of the black seed– black cumin
(Nigella sativa L.).
The technology of preparing suppositories of N. sativa dry extract by fusion molding was proposed, and its
antiulcer activity was studied. The quality of suppositories was assessed according to the following indicators:
characteristics, average weight of suppositories, melting point, identification, quantification. The study of the
antiulcer activity of the drug was carried out on the model of phenolic proctitis. It was found that the tested drug
significantly reduces the area of necrosis, hyperemia, and also significantly reduces the edema and the length of
the damaged section of the intestine relative to the entire length of the rectum, on the model of phenolic proctitis.
The data obtained indicate the presence of reliable antiulcer activity in the tested drug, which gives reason to
recommend it for proctitis, hemorrhoids and in a number of other proctological diseases with concomitant
inflammation, edema, hyperemia and ulceration.

Author Biographies

  • Nigmatkhodjaev Akbarkhodja Bahodirkhodjaevich

    Director, Pharmacy Innovation Centre

  • Abdullabekova Viloyatkhon Nurullabekovna

    Professor, Doctor of Pharmaceutical Sciences, Institute of Pharmaceutical Education and Research,

  • Yunuskhodjaev Akhmatkhodja Nigmanovich

    Professor, Doctor of Pharmaceutical Sciences, Institute of Pharmaceutical Education and Research,

  • Iskandarova Shakhista Fekhruzovna

    Professor, Doctor of Pharmaceutical Sciences, Institute of Pharmaceutical Education and Research,

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Published

2022-10-10

How to Cite

The Development and Standardization of a Proctological Agent Based on Black Cumin (Nigella Sativa L.) Extract. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(4), 335-343. https://doi.org/10.37506/ijfmt.v16i4.18610