Effect of various level of MDMP-4en-PINACA Orally Gavaged to Wistar rats

Authors

  • Nagwan.E. Abbas
  • Elgamel. A. A
  • E. H. Abdelgadir

DOI:

https://doi.org/10.37506/ijfmt.v17i1.18891

Keywords:

MDMB-4en-PINACA, designer drug, Forensic Science; Rat; Toxicity; histopathological

Abstract

This research studied effects MDMB-4en-PINACA on white Wistar rats’ liver, kidney, and heart, as well as their biological
and hematological parameters. For 14 days, 24 male albino rats received orally. First group was the control group; groups
2 and 3 received 5 and 50 mg/kg (bw) MDMB-4en-PINACA. Liver and kidneys deteriorated in treated rats. Small clusters
of inflammatory cells, “cytoplasmic degeneration with karyolysis”, “venous congestion with hemorrhage” and “edema”,
and “steatosis deterioration” were among the liver’s histological abnormalities. Tubular deterioration increased, as did the
appearance of tubular casts, and glomeruli suffered from atrophy followed by an increase in Bowman’s gap in renal tissue.
Tubular also showed signs of disintegration, including the formation of foam cells that seemed empty in the glomerulus.
Myocardial fibers, the central disc nucleus, and endothelial cells were all healthy. The value of HGB, RBC, HCT and MCHC
were higher in groups 2&3 and the values of MCV, MCH and WBC were decreased in groups 2&3. The activity of serum
AST, ALT, ALP and Creatinine Kinase and the concentrations of total protein, Albumin, Triglyceride, Total Bilirubin, Direct
Bilirubin, Urea, and Creatinine in number 2 group and 3 were greater than that of the control. and that of Cholesterol and
HDL were lower in groups 2and 3. According to this research, synthetic cannabis’ (MDMB-4en-PINACA) negative effects are
worse on the liver and kidneys in group 3 than group 2.

Author Biographies

  • Nagwan.E. Abbas

    PhD Student at National Ribat University, College of High Studies and Scientific Research, Institute of
    Forensic Evidence Sciences

  • Elgamel. A. A

    Professor at School of Pharmacy, Ahfad University for women

  • E. H. Abdelgadir

    Associate Professor at department of Forensic Sciences, College of Criminal Justice, Naif Arab University for
    Security Sciences.

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Published

2022-12-21

How to Cite

Effect of various level of MDMP-4en-PINACA Orally Gavaged to Wistar rats. (2022). Indian Journal of Forensic Medicine & Toxicology, 17(1), 41-47. https://doi.org/10.37506/ijfmt.v17i1.18891