Assessment of Serum cholinesterase and Serum Creatinine Phosphokinase Levels in Organophosphorus Poisoning Patients at a Tertiary Care Centre of Northern India

Authors

  • K.K. Gupta
  • Somesh Srivastava
  • Kauser Usman
  • S.C. Chaudhary

DOI:

https://doi.org/10.37506/ijfmt.v17i1.18908

Keywords:

organophosphorus, poisoning, serum cholinesterase, serum Creatinine phosphokinase, severity, correlation.

Abstract

Introduction: Poisoning with Organophosphorus compounds is an important global health problem, possibly
the most common acute poisoning in developing countries. This study was done to correlate the severity of acute
organophosphorus poisoning with serum cholinesterase and serum creatine phosphokinase level.
Materials and Methods: A Prospective observational clinical study was done on 42 patients suspected of
Organophosphorus poisoning of age >15 years admitted to the emergency unit at a tertiary healthcare center in
northern India. Serum cholinesterase levels and serum Creatinine phosphokinase levels were estimated at the
time of admission in all patients and the severity of Organophosphorus poisoning was assessed according to
Peradeniya Organophosphorous Poisoning (POP) Scale.
Results: In this study, among 42 patients of acute organophosphorus poisoning 32(76.2%)were males and
10(23.8%) were females. Our study authors observed a significant correlation between the severity of poisoning
categorized by the POP scale and the serum cholinesterase and Serum CPK level at the time of the patients’ initial
presentation. Also found that there was a significant correlation between serum cholinesterase and serum CPK
with the outcome of the patients.
Conclusion: In our study severity as well as outcomes of OP poisoning was directly correlated with serum
cholinesterase level and serum Creatinine phosphokinase.

Author Biographies

  • K.K. Gupta

    Additional Professor , Department of Medicine, King George’s Medical University, Lucknow (UP), India.

  • Somesh Srivastava

     Senior Resident, Department of Medicine, King George’s Medical University, Lucknow (UP), India

  • Kauser Usman

    Professor Department of Medicine, King George’s Medical University, Lucknow (UP), India

  • S.C. Chaudhary

    Professor Department of Medicine, King George’s Medical University, Lucknow (UP), India

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Published

2022-12-21

How to Cite

Assessment of Serum cholinesterase and Serum Creatinine Phosphokinase Levels in Organophosphorus Poisoning Patients at a Tertiary Care Centre of Northern India. (2022). Indian Journal of Forensic Medicine & Toxicology, 17(1), 128-133. https://doi.org/10.37506/ijfmt.v17i1.18908