Imidaclopride associated Convulsions - A rare case report
DOI:
https://doi.org/10.37506/tf74zn70Keywords:
Imidaclopride, Convulsions, DyselectrolytemiaAbstract
Background: Acute pesticide poisoning is a global health concern, with organophosphorus compounds contributing significantly. Neonicotinoids, like imidacloprid, have emerged as alternative insecticides due to their selective action on pest nervous systems. This case report explores imidacloprid poisoning, emphasizing clinical manifestations and the ongoing search for safer pesticides.
Methods: A 46-year-old male, chronic smoker, and alcoholic, presented with suicidal imidacloprid poisoning. The patient experienced seizures, central nervous system (CNS) depression, hyponatremia, and respiratory arrest, necessitating mechanical ventilation. The case details the comprehensive evaluation, including imaging studies, and presents vital signs, laboratory results, and physical examinations. The patient received supportive care, and the discussion outlines the treatment strategy, highlighting the challenges and successes in managing imidacloprid toxicity.
Conclusion: This case underscores the complexity of imidacloprid poisoning, particularly noting convulsions secondary to hyponatremia. It stresses the need for further research into imidacloprid's metabolic effects and advocates for vigilant monitoring and supportive care in such cases. The report calls for increased reporting to enhance understanding and knowledge sharing regarding the potential toxic effects of imidacloprid, contributing to better management strategies for pesticide poisoning.
References
Tomizawa M, Casida JE. Neonicotinoid insecticide toxicology: Mechanisms of selective action. Annu Rev PharmacolToxicol. 2005;45:247–68.
Mohamed F, Gawarammana I, Robertson TA, Roberts MS, Palangasinghe C, Zawahir S, et al. Acute human self-poisoning with imidacloprid compound: A neonicotinoid insecticide. PLoS One. 2009;4:e5127.
Zhang A, Kayser H, Maienfisch P, Casida JE. Insect nicotinic acetylcholine receptor: Conserved neonicotinoid specificity of [(3)H] imidacloprid binding site. J Neurochem. 2000;75:1294–303.
Lin PC, Lin HJ, Liao YY, Guo HR, Chen KT. Acute poisoning with neonicotinoid insecticides: A case report and literature review. Basic Clin PharmacolToxicol. 2013;112:282–6.
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Copyright (c) 2024 Shashidhara, Savitha V, Derek Jonathan Edwin, Mirza Asgar Baig, Sai Surya Chukkapalli
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