Cardiac metastasis from carcinoma gall bladder - a rare case detected on autopsy
DOI:
https://doi.org/10.37506/sz534p91Keywords:
Carcinoma , cardiac metastasis , gall bladder, rareAbstract
Metastasis to the heart is uncommon compared to other organs, posing notable diagnostic challenges. Incidence in autopsy studies typically ranges between 0.7% and 3.5%. Lung, breast, and hematologic cancers are the main sources of such metastases, leading to varied clinical presentations and severe complications. Postmortem viscera from a 47 year old male with a suspected history of jaundice. Only limited information was available. Gross examination showed a solid mass in the gall bladder with areas of hemorrhage and necrosis, while no other abnormalities were observed in other viscera received. Brain examination showed congested blood vessels, while heart sections exhibited atypical cell deposits in the pericardium and myocardium. Coronary arteries displayed pathological thickening. Lung and liver sections also displayed similar metastatic atypical cell deposits, infiltrating tissue and causing necrosis. Gall bladder examination revealed irregular glandular formations lined with polygonal tumor cells positive for cytokeratin. The final diagnosis based on histomorphological features and immunohistochemistry confirmed gall bladder adenocarcinoma metastasising to the heart, liver and lungs.
References
Al-Mamgani A, Baartman L, Baaijens M, de Pree I, Incrocci L, Levendag PC. Cardiac metastases. Int J Clin Oncol. 2008;13(4):369-72.
Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004;15(3):375-81.
Butany J, Leong SW, Carmichael K, Komeda M. A 30-year analysis of cardiac neoplasms at autopsy. Can J Cardiol. 2005;21(8):675-80.
Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005;6(4):219-28.
Perazzolo Marra M, Thiene G, De Lazzari M, Calabrese F, Lacognata C, Rizzo S et al. Concealed metastatic lung carcinoma presenting as acute coronary syndrome with progressive conduction abnormalities.Circulation. 2012; 125:e499–e502.
Auger D, Pressacco J, Marcotte F, Tremblay A, Dore A, Ducharme A. Cardiac masses: an integrative approach using echocardiography and other imaging modalities. Heart. 2011;97(13):1101-9.
Buckley O, Madan R, Kwong R, Rybicki FJ, Hunsaker A. Cardiac masses, part 1: imaging strategies and technical considerations. AJR Am J Roentgenol. 2011;197(5):W837-41.
Rahbar K, Seifarth H, Schäfers M, Stegger L, Hoffmeier A, Spieker T et al. Differentiation of malignant and benign cardiac tumors using 18F-FDG PET/CT. J Nucl Med. 2012;53(6):856-63
Nova-Camacho LM, Gomez-Dorronsoro M, Guarch R, Cordoba A, Cevallos MI, Panizo-Santos A. Cardiac Metastasis From Solid Cancers: A 35-Year Single-Center Autopsy Study. Arch Pathol Lab Med. 2023;147(2):177-84.
Inoue T, Shiraki K, Fuke H, Yamanaka Y, Miyashita K, Ito K, Suzuki M, Sugimoto K, Murata K, Nakano T. Cardiac metastases of gallbladder carcinoma. World J Gastroenterol. 2005; 11(13): 2048-9.
Gunjiganvi M, Singh KK, Harsha HS, Bipin T. Cardiac metastasis from gallbladder carcinoma. Int J Surg Case Rep. 2013;4(12):1156-8.
Parmar P, Jain P, Gupta V, Kalyan S, Sharma V, Dhamija A. Cardiac Metastasis of Primary Adenocarcinoma of Gall Bladder: Case Report. J medsci clinres. 2018.6(10).159-64.
Siqueira SAC, Tomikawa CS. Intracardiac metastasis of squamous cell carcinoma of the penis. Autops Case Rep. 2013;3(4):23-8.
Gibbs P, Cebon JS, Calafiore P, Robinson WA. Cardiac metastases from malignant melanoma. Cancer: Interdisciplinary International Journal of the American Cancer Society. 1999;85(1):78-84.
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Copyright (c) 2024 Sunaina Hooda, Ruchi Agarwal, Parul, Parveen Rana, Nitika Chawla, Swaran Kaur
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