Unraveling the Pathology of the Rare Marburg Virus Disease ThroughAutopsy: A Case Report

Abstract

Marburg virus disease is a rare, highly infectious, and fatal illness with limited autopsy-based studies. This case
report details the autopsy findings of a woman who died of Marburg virus disease, offering valuable insights into
the pathogenesis of the disease and its effects on various organ systems. The patient initially presented with fever,
nausea, joint pain, and fatigue, which rapidly progressed to multiorgan failure and disseminated intravascular
coagulopathy. Autopsy revealed extensive hemorrhagic manifestations, including ecchymoses, purpura, and
petechiae, on both external and internal surfaces. Significant hemorrhagic effusions were observed in the body
cavities, and multiple organs showed signs of congestion, hemorrhage, and edema.This case report contributes to
the limited autopsy-based literature on Marburg virus disease, emphasizing the importance of considering it in the
differential diagnosis of febrile illnesses in endemic areas and the need for further comprehensive autopsy studies
to guide targeted interventions.