Venomous Remedy: A Case of Sodium Thio Sulfate and Methylene Blue Poisoning
DOI:
https://doi.org/10.37506/7mqtmx41Keywords:
deliberate self poisoning, sodium thiosulate and methylene blue, seizure, intensive care unit; mechanical ventilation; endotracheal tube; patient stress experiencesAbstract
Deliberate self-poisoning by ingestion of chemicals used for agriculture, insecticides and disinfectants used in houses is a common modality of poisoning across the globe. Poisoning by tablets containing sodium thiosulfate and methylene blue used as water purifying agent (both compounds are used for treatment of cyanide poisoning) is rare. Here we report clinical profile, relevant laboratory investigations and management of a rare case of sodium thiosulfate and methylene blue poisoning(a first case of dual ingestion poisoning with above mentioned chemical and pubmed has little case report on such poisoning).
References
Asawari R, Atmaram P, Bhagwan K, Priti D, Kavya S, Jabeen GA. Toxicological pattern of poisoning in urban hospitals of Western India. J Young Pharm. 2017;9(3):315–320. doi: 10.5530/jyp.2017.9.63
Subash Vijaya Kumar, B Venkateswarlu , M Sasikala , G Vijay Kumar,A study on poisoning cases in a tertiary care hospital J Nat Sci Biol Med: 2010 Jul;1(1):35-9, PMID: 22096334, PMCID: PMC3217281
doi: 10.4103/0976-9668.71671
Vikhyat S Bebarta, Matthew Brittain, Adriano Chan. sodium nitrite and sodium thiosulfate are effective against acute cyanide poisoning when administered by intramuscular injection: Ann Emerg Med 2017 Jun;69(6):718-725.e4. doi: 10.1016/j.annemergmed.2016.09.034. Epub 2016 Dec 29
Sodium thiosulfate: calciphylaxis, JoyceA,Generali RPh, and Dennis J.Cada. 2015 Nov 24;50(11):975–977. Doi: 10.1310/hpj5011-975
J Med Toxicology, 2013 May 2;9(3):274–277. doi: 10.1007/s13181-013-0305-z. Severe Anion Gap Acidosis Associated with Intravenous Sodium Thiosulfate Administration, Michael Mao , Sarah Lee , Kianoush Kashani , Robert Albright , Qi Qian
Moeed Ahmed, Thomas sanchez. Rasburicase-Induced Methemoglobinemia, April 2021, Cureus, DOI:10.7759/cureus.14406
Ginimuge PR, Jyothi SD. Methylene blue: revisited. J Anaesthesiol Clin Pharmacol. 2010 Oct;26(4):517-20. [PMC free article] [PubMed] [Reference list]
Ann N Y Acad Sci, 2007 Dec:1122:231-44.doi: 10.1196/annals.1403.016.Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue. Lars Wiklund , Samar Basu, Adriana Miclescu, Per Wiklund, Gunnar Ronquist, Hari Shanker Sharma
JAMA. 1933;100(5):357. doi:10.1001/jama.1933.02740050053028. February 4, 1933. METHYLENE BLUE AS ANTIDOTE FOR CYANIDE POISONING. P. J. Hanzlik
World J Crit Care Med. Sep 9, 2025; 14(3): 105350 Published online Sep 9, 2025. doi: 10.5492/wjccm.v14.i3.105350 Methylene blue in the critical care setting Praveen Reddy Elmati, Teja Nagaradona, Vikas Raghove, Gowthami Sai Kogilathota Jagirdhar, Salim Surani, PMID: 40880565
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Copyright (c) 2026 Binod Biswajeet Rout, Poonam Raj, Vishal Singh, Vikas Marwah, Renubala Pradhan

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