Aging Influence Mitochondrial Dysfunction and Oxidative Stress through Check Some Proinflammatory Cytokines Levels and Oxidant Status in Older Adults: an Observational Study

Abstract

The experiment design is that of a cohort study within the setting of a medium private laboratory with participants being common people (healthy individuals of 20–99 years=108; mean age 55 years and 71.3% man) were classified into six age groups. Oxygen saturation (SpO2), pulse rate, systolic blood pressure (CSBP) and diastolic blood pressure were assessed. Blood sera (once) was obtained for proinflammatory cytokines levels (including c-reactive protein (CRP), insulin growth factor-1 (IGF-1), apolipoprotein E (apoE), interleukin 6 (IL-6), 8-hydroxy-2’–deoxyguanosine (8-OHdG) and tumor necrosis factor-? (TNF-?)) and oxidant status (including malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) analysis. The mean calculated of the whole participants were equal for proinflammatory cytokines levels: CRP 3.24 mg/dL, IGF-1 54.03 ng/mL, apoE 488.29 mg/mL, IL-6 65.464 pg/mL, 8-OHdG 1.34 ng/mL and TNF-? 105.63 pg/mL; and oxidant statue: MDA 0.59 ng/mL, SOD 3.48 U/mL and T-AOC 1.21 mmol/L, receptively. Our findings highlighted that survey of mitochondrial dysfunction and oxidative stress through check some proinflammatory cytokines levels and oxidant status of aging in older adults can be applied to build a global frailty index as a tool to quantify aging in preclinical experiments.