Impact of Aspirin Suppositories on Fertility in Female Mice
Keywords:Mice, aspirin effect, ovaries, uterus
The present study aims to investigate the effect of treatment with vaginal aspirin suppositoriesi(Aspirin), with two deferent concentration on the pregnancy outcome and the proportion of the sex ratio and some reproductivei parameters such as the thickness of the lining of the uterus in female mice. Guaranteei the experimentali work, the division (30) female mouse (10-12) a week and weight (32-52) grams in to three groups (10 mature females mice/group) including one group as control depending on different doses of aspirin suppositories (0.5 mg / kg, 1 mg / kg) and the administration period for 6 Day. The parameters were evaluated include, the study of pregnancy outcome, sex ratio, and histological changes in the uterus endometrial thickness using the pigments (hematoxyline and eosin stains). The resultsi of the current study, a significant improvement (P <0.05) in the studied reproductive parameters using both of doses (0.5 mg / kg, 1 mg / kg) compared with the control group as: ( pregnancy outcome, sex ratio, and histological changes in the endometrial thickness. The results of vaginal dosing for the female mice also showed improvement in the standards mentioned above use high dose(1 mg / kg) of the same drug compared to vaginal delivery of low dose and control group. Therefore, it was concluded that the vaginal supplementation of aspirin probably has important role on the fertility and reproductive parameters and reduce the side effect of aspirin drug in females mice. The present study showed clearly, an enhancement general numbers of embryos, as well as increases in male genders than control group.
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