Levels of Interleukin-10 in Iraqi Childhood Acute Lymphoblastic Leukemia after Chemotherapy

Abstract

Background:- Acute Lymphoblastic Leukemia (ALL) is a group of heterogeneous lymphoid disturbance that results from a monoclonal proliferation and expansion of immature T or B lymphocyte ancestor in the blood, bone marrow, and other organs, Interleukin-10 (IL-10) is a pleiotropic cytokine produced by type 2 helper cells (Th2), as well as macrophages and monocytes and neoplastic B lymphocytes and normal. Aim of this Study: - The aim of this study is to estimate the level of IL-10, and its role as an indication of response to chemotherapy treatment. Experimental part:- A probable group study carry on out at Unit of Oncology / Child Center Teaching Hospital / AL-Iskan / Baghdad city during the period from October 2017 to June 2018. 25 patients with newly diagnosis of ALL. IL-10 levels were measured utilize serological methods included the enzyme-linked immunosorbent assay before and after chemotherapy treatment. Result:- This study was carried out on (25) children patients (11 male, and 13 female) newly diagnosed with ALL. The age rang (1.2 years – 12 years), the mean of age was (5.3±3.3 years). A significant decrease in total serum protein and interlukine-10 was observed after chemotherapy (p<0.001, 0.001 respectively), and significant increase in GOT, GPT was observed after chemotherapy (P=0.012, 1.001 respectively). Conclusion: - The results of our study offering the promising clinical utility of IL-10 as markers of response to chemotherapy.