Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients

Abstract

The study was done in January – may 2018, For measuring interleukin concentration 17-A and transforming growth factor-?1 in the serum of syst.emic lu.pus erythrmatosus (SLE) female patients(52 female) compared to the control group (36 healthy female). An E?zyme- Link ed Immun?s orbent Assay (ELISA) was used to diagnose both IL-17A and TGF ?1 in SLE patients and control. In case of IL-17A High significant in.crease (P < 0.0001) in SLE patients (38.54 pg / mL) compare d with he althy co.ntrol (20.24 pg / mL) was observed, while in patients with SLE, the transforming growth factor-? was (70.90 pg / mL) compared to healthy control (116.66 pg / mL) (P < 0.0001). To all SLE patients and control, The laboratory features include full blood count ,ery.throcyte sedimentation rate ESR, ,an.d immunological tests like C3,C4,ANA and anti ds-DNA were done. ESR , WBC , ANA and Urea were significantly higher in SLE patient than con trol group (p.value 0.0001, 0.0001, 0.024, 0.0001 respectively) whereas Hemoglobin were significantly lower in SLE Patient than control group (p.value 0.0001) .C3&C4 were lower in SLE patients but with no significance value.