Effect of Metronidazole on Clopidogrel Bisulphate Efficacy in Male Albino Rats

Abstract

The data about this combination effect on platelet function and hematological parameters are sparse, but there is only mention in many medical science websites such as Medscape, there are possible interaction between it, in which metronidazole cause inhibition to cytochrome CYP3A4 which responsible on clopidogrel metabolism, this may put the patients that on clopidogrel bisulphate therapy at risk of clot formation and may be progress, this may occur because clopidogrel is at inactive form and need to activation by cytochrome mention above, so this study was performed in order to achieve the following aims: studying the efficacy of clopidogrel bisulphate on coagulation process by measuring bleeding time when giving clopidogrel alone and in combination with metronidazole and studying the possible effect of two drug alone and in combination on hematological parameters in male albino rats