In silico Analysis of “Interferon Beta 1” In some Selected Animal Species

Abstract

Type I interferons (IFNs), are considered as a main host immune system cytokines effector against infectious virus. In addition to ?i?nnat?eim?munerecep?torbac?teriallig?ands and/or bact?erial infections. Furthermore, th?e development o?f kinds I?F?Ns are a?ls?o triggered, suggesting a wider physiological function f?or those cy?tok?inesi?nhom?eostaisi and h?ostprote?ctionth?an initially expected. Results: To recognize both structural divergence and sequence various bioinformatics methods were used. Initial sequence analysis of IFNß1 showed that they shared with human over 70% similarity and some identity like Rhesus monkey, pig , domestic cat ,for dog. With few exceptions, sequences showed a high degree of sequence preservation. The physicochemical analysis indicated a large developmental difference between humans and others and an estimate of 39% to 42% of hydrophobic residues. Four human mammals house mouse pig Norway rat have various Pfam types. The secondary structure of IFNß1 composed of ran?domco?il, Exv?tendedstr?anda?ndAl?phahe?lix. Conclusions: Depending o?nth?eres?ults collected, which maybe assumed th?at in these mammalian species IFNß1 has the same counterpart, highly retained and functional similarities.