Thiophene-Cyclic and Sulfazane Derivatives (Preparation, Spectral Analysis, the Behavior in Organic Solvents, Microbial Testing)

Abstract

The thiophene core is the most broadly applied constructing blocks to the production of many biomolecules ,pharmaceutical drugs ,vitamins ,also in industrial compounds, in dyes compounds because of its high stability in environment. Thiophene derivatives were synthesized in present study from chalcone compound as a starting material from aldol reaction in first step, followed by cyclization reactions by using various conditions, and this paper involved new reaction for diazonium salts to producing (Sulfide- azo) compounds in same bond for the first time that we termed (Sulfazane) as a first and Novel preparation to this new type of compounds.,the synthesized derivatives were confirmed through numerous spectral techniques (FT.IR ,H.NMR ,C.NMR), other physic-chemical data for synthesized thiophene derivatives ,besides to studying of behavior of compounds in organic solvents and screening tests for efficiency of thiophene derivatives against microbes