The effectiveness of Aqueous Extract of Grape Seeds Vitis vinifera as an antibiotic for some microorganisms and its Protective Role Histology for Liver, Kidney in Mice

Abstract

1- Among the common disease treatments and long-term use of plant extract in the treatment of bacterial infections, This research used black grape seed extract to observe its effect on some Gram negative and positive bacteria like Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus mirabillis obtained from patients with urinary tract infection Using four specific extract concentrations (100 mm / L, 75 mm / L, 50 mm / L, 25 mm / L) to test the effect of black grape plant extract. The results showed that E. coli was the most resistant bacterial species to plant extract and so on with other gram negative bacterial species. In the minimum inhibition concentration test for the plant extract, showed that the highest concentration 100 mm / L had the good inhibitory activity for Staph. aureus and less than other strains specially for Kleb. pneumoniae and Pro. mirabillis while the 25mm / L concentration had the lowest acitivity against all. 2- This study used 10-day oral methionine and 30-day grape extract treatment for 16 white mice to study the histopathological effects in the liver, kidney and heart tissues, And the results showed a very good organ tissue improvement for all treated groups compared to the control group.