Association of Adiponectin and IgE levels with occurrence of asthma in Babylon Province

Abstract

ackground : Asthma is a health condition that affects breathing in people. Breathing comfortably is not something most of us need to think about. But if you have asthma, there are times when you have difficulty breathing.The main objectives in the current study are:Determine the role of adiponectin, a hormone that acts as an anti-inflammatory, In addition determine the concentration of immunoglobulin E (IgE) In asthma patients. Method: This study included two groups:Group 1: 80 Patients with asthma were divided into two parts (40 samples obese and 40 samples non-obese).Group 2: 80Group of healthy subjects with no history or clinical evidence of asthma. samples were divided into two parts (40 samples were obese and 40 were not obese). Asthma was diagnosed through a pulmonary function test (PFT) and then invited to a private clinic and measured nitric oxide gas (FeNO) to confirm the diagnosis.Enzyme-linked immunosorbent assay(ELISA ) technique was used to determine the concentration of adiponectin and IgE in serum. Results: The present study demonstrated the increase of adiponectin level with asthmatic patients compared with the control group and showed significant difference between non-obese patients group and non-obese healthy group. Conclusion: Adiponectin related with obesity play crucial role in asthma development and inverse relationship between IgE and adiponectin