Evaluation Inhibin B, FSH, and LH in Male with Thalassemia

Abstract

Background : - Hypogonadism is the most frequently reported endocrine problem, affecting 70–80% of patients with thalassemia.Aim of study: -The current study is aimed to found correlation among inhibinB,FSH, LH and testosteronein male with thalassemia. Material and Subject: The study carried out 40 healthyvolunteermale, age range between (18-30) years,and enrolled 40 patients with thalassemia major age range between 18-30 years. The concentrations serum inhibin-B was estimated by two-side enzymelinked immunosorbent assays (ELISA), While FSH, and LH estimated by using Cobas e analyzers.Results: LH reduce significantly in thalassemia patients when compared with healthy individuals, while FSH and testosterone decrease significantly in thalassemia patients when compared with healthy. Inhibin B was reduced significantly in thalassemia patients when compared with healthy individuals.Conclusion:Infertility common in thalassemia patients, that correlation with decrease inhibin B.