Osteoclastic Activity in Orthodontic Tooth Movement- A Review
Keywords:osteoclast, tooth movement, osteoclastogenesis, prostaglandins, RANKL, bisphosphonates, M-CSF.
It is a well-known concept that bone remodeling occurs during orthodontic tooth movement. The orthodontic
literature is vastly full of information about the changes occurring on the periodontal ligament level.
However, changes occurring in the alveolar bone are being elucidated. What we know about bone resorption
has changed a lot in the last few decades. The osteoclast is the only cell to nibble and breakdown the bone,
and also aids in formation and resorption of bone tissue. In this review, we briefly describe the phases and
theories of tooth movement and also the changes involved during orthodontic tooth movement.