Comparative Evaluation of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids in The Management of Resistant Oral Lichen Planus

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Akshi Choudhary
Upasana Sethi Ahuja
Nidhi Puri Narang
Anuj Agarwal
Anuradha Yadav
Ipshita Yadav

Abstract

Background:Lichen Planus (LP) is a chronic mucocutaneous inflammatory disease that predominantly affects the oral mucosa, with a female predilection. The oral lesions are characterized by burning and pain which relentlessly affect the patient’s quality of life. The available treatment approaches for OLP documented to have a short term effect with potential adverse effects which further increases the demand of a novel therapeutic approach for the severe resistant lesions of OLP with a malignant potential. This double-blind, split-mouth randomized controlled trial aims to evaluate and compare the effectiveness of intralesional Autologous Platelet Rich Plasma and corticosteroid for the management of resistant OLP.Materials and methods: 28 clinically and histopathologically confirmed cases of resistant OLP were included with total 56 lesion sites divided into two groups of 28 each, in group 1 intralesional PRP and in group 2 intrealesional steroid was given. The injections were repeated for consecutive 4 weeks and then kept on regular followup. Parameters recorded on every visit were according to the Modified Escuider Index.Results: A statistically significant reduction in the lesion activity scores was found amongst the group treated with Platelet Rich Plasma as compared to the group treated with intralesional steroids.Conclusion: The use of intralesional PRP in resistant cases of OLP

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How to Cite
Comparative Evaluation of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids in The Management of Resistant Oral Lichen Planus. (2023). Indian Journal of Contemporary Dentistry, 11(2), 1-6. https://doi.org/10.37506/ijocd.v11i2.20053
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Author Biographies

Akshi Choudhary

Senior Lecturer,Department of Oral Medicine & Radiology, I.T.S Dental College, Muradnagar, Ghaziabad.

Upasana Sethi Ahuja

Professor & Head- Department of Oral Medicine & Radiology, SBB dental college, Ghaziabad,3

Nidhi Puri Narang

Private Practitioner,New Delhi

Anuj Agarwal

Senior Lecturer- Department of Oral & maxillofacial surgery, I.T.S Dental College, Muradnagar, Ghaziabad.

Anuradha Yadav

Reader, Department of Oral Medicine & Radiology, I.T.S Dental College, Muradnagar, Ghaziabad, Bharat

Ipshita Yadav

PG student- Department of Oral Medicine & Radiology, I.T.S Dental College, Muradnagar, Ghaziabad, India

How to Cite

Comparative Evaluation of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids in The Management of Resistant Oral Lichen Planus. (2023). Indian Journal of Contemporary Dentistry, 11(2), 1-6. https://doi.org/10.37506/ijocd.v11i2.20053