Correlation between Helicobacter Pylori Infection with Gastroesophageal Reflux Disease Degree

Abstract

Background: Gastroesophageal reflux disease (GERD) is a pathological condition as a result of gastric

contents reflux into the esophagus. Acid reflux is the major irritant for the esophagus in the development

and progression of GERD. A number of theories have developed regarding the correlation of gastric acid

secretion and the development of GERD, one of which has attracted attention and controversy is the effect

of Helicobacter pylori (H. Pylori) infection on acid secretion. This study aims to look at the correlation of

the GERD degree with H Pylori infection.

Methods: This was an observational study with a cross-sectional approach in GERD patients who were

diagnosed based on endoscopic examination at the Gastro Center of Wahidin Sudirohusodo Hospital and

histopathology examination was performed to determine the presence of H. pylori infection from July 2017

to December 2018. Statistical analysis was performed by descriptive and frequency distribution with Chi

Square test statistics using SPSS 25

Results: There were 151 subjects, 85 male subjects (56.3%) and 66 female subjects (43.7%), 20 subjects

(13.2%) of whom had H. pylori infection. In this study the GERD degree was more mild with H. pylori

infection than with negative H. pylori infection, but the correlation was not statistically significant.

Conclusion: The degree of GERD in H. pylori infection is more mild though there is no significant

correlation.