Endometrial Estrogen and Progesterone Receptor Expression  and Blood Vessel Density in Abnormal Uterine Bleeding

Authors

Pradyot Singh1 , Mamta Gupta2, Rani Bansal3 , Davender Swarup4 , Mitali Singhal5

Abnormal uterine bleeding, Endometrial Carcinoma Estrogen receptor, immunohistochemistry, hyperplasia, Progestrone receptor

Background: The aim of present study was to analyse endometrial estrogen and progesterone receptor

expression and blood vessel density in cases of abnormal uterine bleeding.

Material and Method: The present study was conducted on specimens received from 266 patients presenting

with abnormal uterine bleeding in reproductive age group (18-45 years) on endometrial biopsies and

hysterectomy specimens. The intensity and distribution of ER, PR was evaluated using a semi-quantitative

method Allred score. Also density of blood vessels /10 HPF was evaluated.

Results: Neoplastic cases were found among 9.4% (25) of the subjects whereas non-neoplastic lesions

were present in 90.6% (241) of the subjects. Mean Allred scoring of estrogen and progesterone receptor in

glandular component was highest among endometrial carcinoma. Mean Allred scoring of estrogen receptor in

stromal component was highest among Hyperplasia without atypia (5.13±1.58). Mean progesterone receptor

in stroma component was highest among Hyperplasia without atypia followed by disordered maturation and

endometrial carcinoma.

Conclusion: The results of the present study showed that ER and PR expression are useful investigations.

There expression varies in various causes of abnormal bleeding. Future studies with clinical trials could be

done to try medical treatment of AUB.

Pradyot Singh1 , Mamta Gupta2, Rani Bansal3 , Davender Swarup4 , Mitali Singhal5

1Postgraduate Student, 2 Associate Professor, 3 HOD, 4 Professor, 5 Assistant Professor, Department of Pathology,

Subharti Medical College, Swami Vivekanand Subharti University, Meerut