Hemostatic Parameter of Acute Lymphoblastic Leukemia-L1 with Hyperleukocytosis

Abstract

Background. The increasing rate of morbidity and mortality in leukemic patients are frequently found in

hyperleukocytosis state. Hyperleukocytosis is defined by a white blood cell count more than 50.000/mm3.

Hyperleukocytosis still becomes an oncologic emergency that need immediate treatment. The complications

that will develop if it is not immediately treated is hemostatic disorder such as intracranial bleeding and

pulmonal bleeding.

Objective. This study aimed to assess the differentiation of hemostatic parameters between ALL-L1 with

hyperleukocytosis and without hyperleukocytosis

Methods. The study was a cross sectional study at conducted in DR. Wahidin Sudirohusodo Hospital from

November 2016 to April 2017 with seventy-two patients aged 1 month–18 years old were diagnosed with

ALL-L1 based on BMP result. They were divided into two groups, 31 patients with hyperleukocytosis and

41 without hyperleukocytosis. Then they were assessed by hemostastic parameters laboratory examination

(Platelet, PT, APTT, D-Dimer, and Fibrinogen).

Result. There was no significant difference in platelet count, PT, APTT, D-Dimer and fibrinogen levels

between ALL-L1 patients with hyperleukocytosis and without hyperleukocytosis. Mean of platelet count

with p value = 0.621, mean PT with p value = 0.429, mean APTT with P value = 0.918, mean D-Dimer with

p value = 0.882 and mean fibrinogen with p value = 0.455.

Conclusion. There was no significant difference of haemostatic parameters between ALL-L1 patients with

hyperleukocytosis and without hyperleukocytosis.