Evaluation of Plasma Protein Alpha 2 and Beta in the Patients of Hepatitis B and C Virus by Radial Immunodiffusion Technique (RID)

Abstract

Proteins usually found in all body fluids, the proteins it is only of the blood plasma that are examined utmost

frequently for diagnostic purposes. Over 100 proteins individual have a physiological mission in the plasma,

plasma protein Mostly synthesize by liver, usually exclusion of protein hormones and immunoglobulins. In

this study include the twenty four patients suffering from infection hepatitis C virus and twenty four patients

suffering from infection hepatitis B virus. The estimation of plasma proteins alpha 2 kind are ceruloplasmin

and haptoglobin and beta type is transferrin concentration by used radial immunodiffusion technique (RID).

The transferrin and haptoglobin are affected, the transferrin is decline below the normal value while the

haptoglobin contain the normal value. The twenty patients from each of the HCV and HBV transferrin

concentration were (105 - 109) mg/dl, while ceruloplasmin (17.4 - 49.4) mg/dl and haptoglobin (71.2 - 100)

mg/dl. The concentration of the last two were the normal value haptoglobin and ceruloplasmin levels that as

measured in this study, Thus, it could possibly be assumed that the level of ceruloplasmin was not affected

to an extent that is clinically significant.

Consequently, it is justifiable to conclude that reporting blood levels of ceruloplasmin is not of clinical value

to HBV and HCV patients. Furthermore, this study showed the transferrin and haptoglobin level were the

marker (out of the three) that were affected in patients with HBV and HCV when its level was compared

with levels in healthy individuals, it was significant and the transferrin P (0.001), haptoglobin P (0.003).

The reduction in transferrin level and increase in haptoglobin found by this study may be well linked with

increased serum iron levels reported in HBV and HCV patients and the level of the fibrosis liver.