Relationship of Blood Vitamin-D Levels on Neoadjuvant Chemotherapy Response of Caf (Tumor Size Based on Ultrasonographic Examination) in Post Menopause Women With Locally Advance Breast Cancer in Dr. Soetomo General Hospital Surabaya

Abstract

Background : Breast cancer is one of the most prevalent cancer in Indonesia and the most prevalent cancer
in women. Patients in Dr. Soetomo Hospital Surabaya generally comes in an advanced stage condition
(locally advanced breast cancer). 52% of the patients with breast cancer in Dr. Soetomo hospital did not
respond well to chemotherapy treatment. This is related to low levels of vitamin D in the blood, which
decreases the therapeutic response of breast cancer.
Method: The design of this research is a prospective cohort of patients with locally advanced breast
cancer. Patients were examined for vitamin D levels and tumor mass size 1 day before the chemotherapy
regiment was carried out and after 3 of CAF chemotherapy regimens were administered, an evaluation of
the therapeutic response in patients was done by comparing tumor mass size before and after chemotherapy
with ultrasound.
Results: There were 30 patients evaluated. 17 people (56.7%) with low level of vitamin D and 13 (43.3%)
with normal level of vitamin D. The therapeutic response was obtained as follow, 13 people (43.3%) with
partial response, 16 people (53.3%) with stable disease, and 1 person (3.3%) with progressive disease.
Statistical tests proved a significant relationship between levels of vitamin D with chemotherapy response in
patients with locally advanced breast cancer (p = 0.026).
Conclusion: There is a relationship between levels of vitamin D in blood with the size of the tumor, based
on ultrasound examination, as a response to neoadjuvant chemotherapy of CAF in postmenopausal women
with locally advanced breast cancer in Dr. Soetomo General Hospital Surabaya