Polymorphism gen Follicle Stimulating Hormone Receptor Ala307 Thr (rs 6165) and Ser 680 Asn (rs 6166) Related to Polycystic Ovary Syndrome with Insulin Resistance
DOI:
https://doi.org/10.37506/ijphrd.v11i11.11396Keywords:
Ala 307Thr, Ser 680 Asn, Restensi insulin, SOPKAbstract
Follicle stimulating hormone (FSH) has an important role in female reproduction, follicular development
and ovarian steroidogenesis, through binding to FSH with its receptors in ovarian granulosa cells. The
study design used was a study with an observational approach with a cross sectional approach, which is a
group of cases originating from subjects with Polycystic Ovary Syndrome (SOPK). Wahidin Sudirohusodo
and hospital education network and private hospitals. there was no significant relationship between the
occurrence of FSHR Ala307Thr gene polymorphism with the incidence of insulin resistance Odd Ratio, 95%
Confidence Interval 0.69 (0.23-2.12) with a value of p = 0.518. The same was also found in the Ser680Asn
FSHR gene polymorphism with the incidence of insulin resistance Odd Ratio, 95% Confidence Interval 0.70
(0.27-1.84) with a p value = 0.470, as well as the polymorphism of the G935A LHR gene with the incidence
of insulin resistance Odd Ratio , 95% Confidence Interval 2.24 (0.88-5.73).
