Impact of Sesame Oil for Abrogating Hepatic Oxidative Stress Actuated by Aluminum Chloride in Male Rats

Abstract

The hepatoprotective effect of sesame oil (SO) was evaluated against aluminum chloride (AlCl3) induced
hepatic tissue damage in male rats. A total of twenty four male rats were used and grouped into four groups
of six rats each. AlCl3 induced hepatic tissue damage, marked by increased the activities of aspartate
transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase
(LDH), and bilirubin levels, and a significant decrease in total protein and albumin levels when compared
with the normal control. Also, the level of malodealdehyde (MAD) in the liver tissue was significantly
increased. Whereas, the activities of superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT)
enzymes were markedly decreased. Supplementation of AlCl3 treated rats with SO could improve most of
the biochemical alterations. The results of the present study prove that SO has a potent hepatoprotective
effect against AlCl3 induced oxidative stress injury in hepatic tissues of male rats.