Immunohistochemical assessment of MMR Proteins, BRAF Mutation and Beta-Catenin in Colorectal Carcinoma in Egypt
DOI:
https://doi.org/10.37506/ijphrd.v12i1.13869Keywords:
CRC, dMMR, BRAF mutation, Beta-Catenin, immunohistochemistry, prognosisAbstract
We conduct this study to investigate the prevalence of dMMR, BRAFV600E mutation and nuclear BetaCatenin among Egyptian CRC cases and correlate results with clinico-pathological parameters and survival.
Immunohistochemical assessment of MMR, BRAF and Beta-Catenin was carried out on 83 CRC cases.
dMMR, BRAFV600E mutation and nuclear Beta-Catenin expression were identified in (48.2%), (20.5%)
and(4.8%)of cases. For MMR and BRAF, none of the clinicopathologic parameters were significantly
correlated with their status. Despite that the 5-year PFS was slightly better in dMMR tumors than pMMR
tumors; yet, the statistical difference could not be verified. BRAF mutation had no prognostic impact on
OS and PFS. The smaller number of Beta-Catenin positive tumors precluded the drawing of definitive
conclusion concerning its prognostic role.
