Predictive Factors Associated with Ovarian Hyperstimulation Syndrome in Indonesian Women Undergoing IVF

Abstract

Background: In line with the increasing practice of in-vitro fertilization, it is crucial to pay attention onits
complications. The most common iatrogenic complication of assisted reproductive technologies (ART)
is ovarian hyperstimulation syndrome (OHSS). Several characteristics are useful in identifying high-risk
patients in order to prevent OHSS.
Method: This study analysed characteristics of age, body mass index (BMI), antral follicle count (AFC),
estradiol levels, and the number of oocytes between two unpaired groups of 20 women with OHSS and 19
women, who did not experience OHSS.
Results: The characteristics of AFC (p = 0.012), estradiol levels (p <0.001), and the number of oocytes (p
<0.001) showed were significantly different between the two groups. Women with higher AFC were more
likely to have OHSS, with OR of 3.33 (95% CI 0.77–14.31). Additionally, women with higher levels of
estradiol and number of oocytes were also more likely to have OHSS, OR 76.5 (95% CI 9.66–605.67) and
81 (95% CI 4.2–1561.6), respectively. Other patient’s characteristics did not differ significantly (p> 0.05).
Conclusions: Women with AFC above ten follicles, estradiol levels above 3000 pg/ml, and oocytes count
of more than 12 were more likely to develop OHSS.