Correlation between 25-Hydroxyvitamin D Serum Levels with Telomere Length in Premenopausal Minangkabau Ethnicity Women

Abstract

Background: Aging is associated with an increased prevalence of non-communicable diseases.
Premenopause is a phase in aging characterized by reducing the biological functions of cells. Aging can
be measured by cell biomarker, namely telomeres. Telomere length can be influenced by various factors
including vitamin D. Vitamin D acts as an anti-proliferation and anti-inflammatory cell. This study aimed to
examine the relationship between 25-hydroxy vitamin D serum levels with telomere length of Minangkabau
premenopausal women in Padang city.
Method: This cross-sectional study was recruited ninety-three Minangkabau premenopausal women
in Padang city. The recruitment subject was using a multistage random sampling technique. 25-hydroxy
vitamin D serum levels were measured by the ELISA method. Telomeres length was measured by qPCR
using O’Challagan & Fennech method. The analysis was carried out by univariate and bivariate with Pearson
correlation.
Results: The average serum 25-hydroxy vitamin D levels were 27.79±1.38 ng/ml. The average telomere
length was 474.13 ± 2.02 bp. There was a correlation between 25-hydroxy vitamin D serum levels with
telomere length (r = 0.267, p = 0.01).
Conclusion: This study concluded that there was a correlation between 25-hydroxy vitamin D serum
levels with telomere length of Minangkabau premenopausal women in Padang city. An increase of 1 ng/ml
25-hydroxy vitamin D serum levels slowed down telomere shortening 0,583 bp.