Subtotal Nephrectomy as a Model of Chronic Kidney Disease: A Systematic Review


  • Putu Nita Cahyawati
  • Bagus Komang Satriyasa



chronic kidney disease, subtotal nephrectomy, animal model, procedure


Background: Subtotal nephrectomy (5/6 nephrectomy) is one of the most widely used animal models for
modifying chronic kidney disease. Animal models of kidney disease play an important role to understand
pathophysiology, progressivity, and therapies for the disease. The development of animal models that mimic
the conditions in human disease is still a challenge.
Methods: We conducted a systematic search in the main biomedical databases MEDLINE (PubMed) and
the Directory of Open Access Journals (DOAJ)
Conclusion: The subtotal nephrectomy procedure is a good model for chronic kidney disease. The kidney
damage on this model most closely mimics with kidney damage in humans. This procedure used to remove
or destroys 5/6 parts of the kidney, leaving only 1/3 of the kidney mass. There are variations to this procedure.
Variations included in the type of incision, the location of the uninephrectomy, the type of ligase/ablation,
the operation stage (one or two steps), the length of time between 2 operating procedures, the length of time
for observation, and the type of animal used. Variations procedure in subtotal nephrectomy model have
different effects on biochemical parameters, morphology, and markers of kidney damage.

Author Biographies

Putu Nita Cahyawati

Department of Pharmacology and Pharmacy, Faculty of Medicine and Health Sciences, Warmadewa University,
Jl. Terompong No 24 Denpasar 80235, Bali, Indonesia

Bagus Komang Satriyasa

Department of Pharmacology and Therapy, Faculty of
Medicine, Udayana University, Jl. PB Sudirman Denpasar 80223, Bali, Indonesia



How to Cite

Putu Nita Cahyawati, & Bagus Komang Satriyasa. (2021). Subtotal Nephrectomy as a Model of Chronic Kidney Disease: A Systematic Review. Indian Journal of Public Health Research & Development, 12(3), 150-157.