Multifocalelectroretinography Result before and after Peribulbar Injection of Allogeneic Umbilical Cord – Mesenchymal Stem Cell Secretome for Late-Stage Retinitis Pigmentosa
Keywords:Retinitis Pigmentosa, Secretome, Umbilical Chord, Allogeneic,Electroretinogram.
Background: Retinitis Pigmentosa (RP) is a rare retinal genetic disease without available treatment to date.
Previous studies show growth factor and regenerative ability of secretome from cultured allogeneic umbilical
chord mesenchymal stem cells (UC-MSC). This studyaimed to report multifocal electroretinography of
retinal photoreceptor responsefrom RP patients, before and after injection of secretome from allogeneicUCMSC.
Patients and Methods: Four subjects with severely damage retina (visual field defect of 25 %- 50% in
initial Humphrey perimetry examination) were recruited and givenperibulbar injection of secretome from
allogeneic cultured UC-MSC. Visual acuity, visual field examination, multifocal electroretinogram of retinal
photoreceptor examination were observed before and periodically after injection until six months period
Results: Overall, we observed subtle changes in N1 and P1 amplitude and implicit time only in ring 1 at 1,
3 and 6 month post secretome injection.
Conclusion: Peribulbar injection of allogeneic UC-MSC secretome had very miminal influence on
photoreceptor activity in late-stage RP patients.
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