Multifocalelectroretinography Result before and after Peribulbar Injection of Allogeneic Umbilical Cord – Mesenchymal Stem Cell Secretome for Late-Stage Retinitis Pigmentosa

Authors

  • Cosmos Octavianus Mangunsong
  • Yohanes Widodo Wirohadidjojo
  • Melita Suwan Djaja
  • Cynthia Retna Sartika
  • Andi Wijaya
  • Bayu Winata Putera
  • Muhammad Bayu Sasongko

DOI:

https://doi.org/10.37506/ijphrd.v12i3.16081

Keywords:

Retinitis Pigmentosa, Secretome, Umbilical Chord, Allogeneic,Electroretinogram.

Abstract

Background: Retinitis Pigmentosa (RP) is a rare retinal genetic disease without available treatment to date.
Previous studies show growth factor and regenerative ability of secretome from cultured allogeneic umbilical
chord mesenchymal stem cells (UC-MSC). This studyaimed to report multifocal electroretinography of
retinal photoreceptor responsefrom RP patients, before and after injection of secretome from allogeneicUCMSC.
Patients and Methods: Four subjects with severely damage retina (visual field defect of 25 %- 50% in
initial Humphrey perimetry examination) were recruited and givenperibulbar injection of secretome from
allogeneic cultured UC-MSC. Visual acuity, visual field examination, multifocal electroretinogram of retinal
photoreceptor examination were observed before and periodically after injection until six months period
Results: Overall, we observed subtle changes in N1 and P1 amplitude and implicit time only in ring 1 at 1,
3 and 6 month post secretome injection.
Conclusion: Peribulbar injection of allogeneic UC-MSC secretome had very miminal influence on
photoreceptor activity in late-stage RP patients.

Author Biographies

Cosmos Octavianus Mangunsong


Researcher, PhD Student, Department of Ophthalmology, Faculty of Medicine Public Health and Nursing,
Universitas Gadjah Mada, Yogyakarta, Indonesia, 
PhD Student, Jakarta Eye Center Hospitals, Jakarta,
Indonesia

Yohanes Widodo Wirohadidjojo

Professor, Department of Dermato-Venereology, Faculty of Medicine Public Health and Nursing,
Universitas Gadjah Mada,

Melita Suwan Djaja

Researcher, Ophthalmologist, Department of Dermato-Venereology, Faculty of
Medicine Public Health and Nursing, Universitas Gadjah Mada

Cynthia Retna Sartika

Scientist, Prodia Stem Cell Laboratory, Jakarta,
Indonesia

Andi Wijaya

Scientist, Prodia Stem Cell Laboratory, Jakarta,
Indonesia,

Bayu Winata Putera

Scientist, Prodia Stem Cell Laboratory, Jakarta,
Indonesia

Muhammad Bayu Sasongko

Professor, Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas
Gadjah Mada, Yogyakarta, Indonesia

Published

2021-06-03

How to Cite

Cosmos Octavianus Mangunsong, Yohanes Widodo Wirohadidjojo, Melita Suwan Djaja, Cynthia Retna Sartika, Andi Wijaya, Bayu Winata Putera, & Muhammad Bayu Sasongko. (2021). Multifocalelectroretinography Result before and after Peribulbar Injection of Allogeneic Umbilical Cord – Mesenchymal Stem Cell Secretome for Late-Stage Retinitis Pigmentosa. Indian Journal of Public Health Research & Development, 12(3), 322-329. https://doi.org/10.37506/ijphrd.v12i3.16081