Metallothionein and Malondialdehyde Correlation in Prostate Cancer Patients

Authors

  • Nendyah Roestijawati
  • Yudhi Wibowo
  • Diah Krisnansari
  • Dwi Arini Ernawati

DOI:

https://doi.org/10.37506/ijphrd.v12i3.16128

Keywords:

metallothionein, malondialdehyde, prostate cancer

Abstract

Prostate cancer can be caused by heavy metals exposure that can be identified from increasing levels of
metallothionein. Exposure to heavy metals is carcinogenic through the formation of ROS in the oxidative
stress process. One of the markers of oxidative stress in prostate cancer is malondialdehyde. Purpose of
study to determine the relationship between levels of metallothionein and malondialdehyde in prostate
cancer. Research design was cross sectional with subjects were 30 patients with prostate cancer at district
hospital at Purwokerto, Indonesia. Measurement levels of metallothionein and malondialdehyde used
ELISA sandwich method. Data analysis used Spearman correlation test. There was a correlation between
levels of metallothionein and malondialdehyde (p <0.05, r = 0.36). The increase of metallothionein level
cause enhancement malondialdehyde level. As a conclusion, study report that there was corelation between
metallothionein and malondialdehyde levels illustrates the process of oxidative stress on prostate cancer due
to heavy metals exposure.

Author Biographies

Nendyah Roestijawati

Assistant Professor, Department of Community Medicine, Faculty of Medicine Universitas Jenderal Soedirman, Purwokerto, Indonesia

Yudhi Wibowo

Assistant Professor, Department of Community Medicine, Faculty of Medicine Universitas Jenderal Soedirman,Purwokerto, Indonesia

Diah Krisnansari

Assistant Professor, Department of Community Medicine, Faculty of Medicine Universitas Jenderal Soedirman,Purwokerto, Indonesia

Dwi Arini Ernawati

Assistant Professor, Department of Community Medicine, Faculty of Medicine Universitas Jenderal Soedirman,Purwokerto, Indonesia

Published

2021-06-03

How to Cite

Roestijawati, N. ., Wibowo, Y. ., Krisnansari, D. ., & Ernawati, D. A. . (2021). Metallothionein and Malondialdehyde Correlation in Prostate Cancer Patients. Indian Journal of Public Health Research & Development, 12(3), 577-580. https://doi.org/10.37506/ijphrd.v12i3.16128