Metallothionein and Malondialdehyde Correlation in Prostate Cancer Patients

Abstract

Prostate cancer can be caused by heavy metals exposure that can be identified from increasing levels of
metallothionein. Exposure to heavy metals is carcinogenic through the formation of ROS in the oxidative
stress process. One of the markers of oxidative stress in prostate cancer is malondialdehyde. Purpose of
study to determine the relationship between levels of metallothionein and malondialdehyde in prostate
cancer. Research design was cross sectional with subjects were 30 patients with prostate cancer at district
hospital at Purwokerto, Indonesia. Measurement levels of metallothionein and malondialdehyde used
ELISA sandwich method. Data analysis used Spearman correlation test. There was a correlation between
levels of metallothionein and malondialdehyde (p <0.05, r = 0.36). The increase of metallothionein level
cause enhancement malondialdehyde level. As a conclusion, study report that there was corelation between
metallothionein and malondialdehyde levels illustrates the process of oxidative stress on prostate cancer due
to heavy metals exposure.