Sepsis, a Common Endpoint to Even Non-Infectious Comorbidities, A Single Center Study on 49,107 Patients, at a Tertiary Care Center in India
Keywords:Cerebrovascular accident, Coronary artery disease, Diabetes, Hypertension, infection, sepsis, septic shock, Thyroid.
Background & Objectives- Sepsis, is caused by dysregulated host response that leads to multiple organ
dysfunction. Complications of sepsis being so grave, it becomes important to address it in a community
setting as sepsis always presents itself as a reason for clinical deterioration of preventable and common
Methods- Analysis of in-patient records of 49,107 at a tertiary care centre in India were analysed from
years 2016-2020, to study correlation of sepsis with various comorbidities such as Diabetes, Hypertension,
Coronary artery disease, Cerebrovascular accident and Thyroid; and also, to study the death toll occurring
due to sepsis.
Results- Sepsis has a higher prevalence in the vulnerable age groups that is > 60 years followed by < 20
years of age. Sepsis is observed more in males (56.32%) than females (43.68%). Sepsis was found to have
a statistically significant association (P<0.0001) with Diabetes, Hypertension, Coronary artery disease and
cerebrovascular accident. 38% of total deaths that occurred in the hospital were due to sepsis. 68.9% of
patients who died due to sepsis were ICU cases.
Interpretations & Conclusions- Septic patients are 9 times more prone to death than non-septic patients
in an Intensive care unit. There is no statistically significant association between thyroid disorder and sepsis
(P=0.38). Generally, a researcher would expect diabetes to be a major contributor to sepsis, however our
paper reports 70% of total septic cases to be non-diabetic ones. Sepsis itself is caused due to microbial
infections but the comorbidities contributing to its prevalence are non-infectious in nature.
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