Sepsis, a Common Endpoint to Even Non-Infectious Comorbidities, A Single Center Study on 49,107 Patients, at a Tertiary Care Center in India

Authors

  • Dhaval Dalal
  • Girish Rathod
  • Kamalpriya Thiyagarajan
  • Namrata Britto
  • Veda Devakumar
  • Vijaykumar Gawali

DOI:

https://doi.org/10.37506/ijphrd.v12i4.16513

Keywords:

Cerebrovascular accident, Coronary artery disease, Diabetes, Hypertension, infection, sepsis, septic shock, Thyroid.

Abstract

Background & Objectives- Sepsis, is caused by dysregulated host response that leads to multiple organ
dysfunction. Complications of sepsis being so grave, it becomes important to address it in a community
setting as sepsis always presents itself as a reason for clinical deterioration of preventable and common
diseases.
Methods- Analysis of in-patient records of 49,107 at a tertiary care centre in India were analysed from
years 2016-2020, to study correlation of sepsis with various comorbidities such as Diabetes, Hypertension,
Coronary artery disease, Cerebrovascular accident and Thyroid; and also, to study the death toll occurring
due to sepsis.
Results- Sepsis has a higher prevalence in the vulnerable age groups that is > 60 years followed by < 20
years of age. Sepsis is observed more in males (56.32%) than females (43.68%). Sepsis was found to have
a statistically significant association (P<0.0001) with Diabetes, Hypertension, Coronary artery disease and
cerebrovascular accident. 38% of total deaths that occurred in the hospital were due to sepsis. 68.9% of
patients who died due to sepsis were ICU cases.
Interpretations & Conclusions- Septic patients are 9 times more prone to death than non-septic patients
in an Intensive care unit. There is no statistically significant association between thyroid disorder and sepsis
(P=0.38). Generally, a researcher would expect diabetes to be a major contributor to sepsis, however our
paper reports 70% of total septic cases to be non-diabetic ones. Sepsis itself is caused due to microbial
infections but the comorbidities contributing to its prevalence are non-infectious in nature.

Author Biographies

Dhaval Dalal

Professor, Internal Medicine, Department of Internal Medicine, Consultant Internal medicine

Girish Rathod

Head ofOrthopedic Department, Consultant Orthopaedician, Bhaktivedanta Hospital and Research Institute, Thane,Maharashtra, India, Bhaktivedanta Hospital and Research Institute

Kamalpriya Thiyagarajan

Professor, Gynaecology and Obstetrics,DGO, Consultant Obstetrician & Gynaecologist, Medical Research Department, Bhaktivedanta Hospital and Research Institute

Namrata Britto

Research Scholar, MSc. Biological Sciences, Department of Biological Sciences, Sunandan
Divatia School of Science, NMIMS, Deemed to be University, Thane, Maharashtra, India

Veda Devakumar

Research Scholar,Department of Medical Research, Bhaktivedanta Hospital and Research Institute, Bhaktivedanta swami Marg,sector 6, Srishti complex, Mira Road, Thane: 401107, Maharashtra, India

Vijaykumar Gawali

Researcher,Head of Medical Research department and Academics,Bhaktivedanta Hospital and Research Institute

Published

2021-07-19

How to Cite

Dalal, D. ., Rathod, G. ., Thiyagarajan, K. ., Britto, N. ., Devakumar, V. ., & Gawali, V. . (2021). Sepsis, a Common Endpoint to Even Non-Infectious Comorbidities, A Single Center Study on 49,107 Patients, at a Tertiary Care Center in India. Indian Journal of Public Health Research & Development, 12(4), 49-56. https://doi.org/10.37506/ijphrd.v12i4.16513