Analysis of N-Terminal Fragment B Type Natriuretic Peptide Serum In Chronic Kidney Disease

Authors

  • Nelly Tolla
  • Rachmawati A. Muhiddin
  • Fitriani Mangarengi

DOI:

https://doi.org/10.37506/ijphrd.v12i4.16551

Keywords:

Chronic Kidney Disease, NTProBNP, Glomerular Filtration Rate, Hypertension

Abstract

Chronic kidney disease (CKD) is a condition of decreased kidney function due to chronic and irreversible
renal parenchymal damage. Chronic kidney disease is one of the world’s health problems due to its
high prevalence of the disease, increasing morbidity and mortality rates and expensive treatment costs.
Cardiovascular complications have been recognized as the leading cause of death in CKD. Left ventricular
hypertrophy (LVH), systolic and diastolic dysfunction are the most common cardiovascular complications
found in CKD. NTproBNP is an early diagnostic and prognostic biomarker of cardiovascular diseases,
hence it can distinguish between acute and chronic cardiovascular diseases. Therefore, this examination is
recommended to monitor patient treatment. NTproBNP levels circulating in the circulations of cardiovascular
patients are about six times higher than other biomarkers including BNP. This study aims to assess serum
NTproBNP levels in various degrees of CKD. This research is an observational analytic study with cross
sectional approach. It was conducted between June and August 2019 at Dr. Wahidin Sudirohusodo hospital
with total sample of 86 patients diagnosed with CKD who met the inclusion and exclusion criteria. Based
on the Kruskal Wallis test, which were used due to abnormal data distribution, a significant difference was
found in serum NTProBNP levels based on the degree of CKD with the initial increase occured in grade III
CKD with mean value of 4,653 ng/L. Serum NTproBNP levels were not significantly different based on the
degree of hypertension. Serum NTProBNP levels were significantly correlated with urea and creatinin levels
and GFR value based on the Rho Spearman correlation test with a p value <0.05.

Author Biographies

Nelly Tolla

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University-Dr.Wahidin Sudirohusodo
Hospital Makassar, Indonesia. Jl. Perintis Kemerdekaan Tamalanrea, Makassar, Telp. (0411)581226.
Department of Physiology, Faculty of Medicine, Unismuh University Makassar, Indonesia. Jl. Sultan Alauddin
No.259 Makassar

Rachmawati A. Muhiddin

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University-Dr.Wahidin Sudirohusodo
Hospital Makassar, Indonesia. Jl. Perintis Kemerdekaan Tamalanrea, Makassar, Telp. (0411)581226.
Department of Physiology

Fitriani Mangarengi

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University-Dr.Wahidin Sudirohusodo
Hospital Makassar, Indonesia. Jl. Perintis Kemerdekaan Tamalanrea, Makassar, Telp. (0411)581226.
Department of Physiology

Published

2021-07-19

How to Cite

Nelly Tolla, Rachmawati A. Muhiddin, & Fitriani Mangarengi. (2021). Analysis of N-Terminal Fragment B Type Natriuretic Peptide Serum In Chronic Kidney Disease. Indian Journal of Public Health Research & Development, 12(4), 247-254. https://doi.org/10.37506/ijphrd.v12i4.16551