Analysis of N-Terminal Fragment B Type Natriuretic Peptide Serum In Chronic Kidney Disease
Keywords:Chronic Kidney Disease, NTProBNP, Glomerular Filtration Rate, Hypertension
Chronic kidney disease (CKD) is a condition of decreased kidney function due to chronic and irreversible
renal parenchymal damage. Chronic kidney disease is one of the world’s health problems due to its
high prevalence of the disease, increasing morbidity and mortality rates and expensive treatment costs.
Cardiovascular complications have been recognized as the leading cause of death in CKD. Left ventricular
hypertrophy (LVH), systolic and diastolic dysfunction are the most common cardiovascular complications
found in CKD. NTproBNP is an early diagnostic and prognostic biomarker of cardiovascular diseases,
hence it can distinguish between acute and chronic cardiovascular diseases. Therefore, this examination is
recommended to monitor patient treatment. NTproBNP levels circulating in the circulations of cardiovascular
patients are about six times higher than other biomarkers including BNP. This study aims to assess serum
NTproBNP levels in various degrees of CKD. This research is an observational analytic study with cross
sectional approach. It was conducted between June and August 2019 at Dr. Wahidin Sudirohusodo hospital
with total sample of 86 patients diagnosed with CKD who met the inclusion and exclusion criteria. Based
on the Kruskal Wallis test, which were used due to abnormal data distribution, a significant difference was
found in serum NTProBNP levels based on the degree of CKD with the initial increase occured in grade III
CKD with mean value of 4,653 ng/L. Serum NTproBNP levels were not significantly different based on the
degree of hypertension. Serum NTProBNP levels were significantly correlated with urea and creatinin levels
and GFR value based on the Rho Spearman correlation test with a p value <0.05.
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