The Difference of Brain Derivat Neutrophic Factor of Mus Musculus Newborn from Adolescent and Adult Pregnancy

Abstract

Background: The brain is the main organ involved in stress adaptation, while being the target of stress.
Stress activates the hypothalamic-pituitary-adrenal (HPA) axis and the system is adrenomedular Simpato
thereby increasing the production of corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP)
resulting in lower levels of Brain Derived Neurotrophic Factor (BDNF) in the hippocampus. Objective: The
study aims to find out the difference of BDNFof Mus musculus newborn brain fromadolescents and adults
pregnancy. Method: The samples on this study were 32 mice that divided by 2 groups were adolescent
pregnancy mice group and adult pregnancy mice group. Mus musculus newborn were born by sectio and
selected three with the heaviest, medium and lightest of each mothers to sacrificed their brains did decapitated
and made immunohypochemical preparations and continued examination of the Immunoreactive Score to
calculate Brain Derived Neurotrophic Factor expression. Result: BDNF expression of adolescent pregnancy
mice group had higher (5.65±1.044) than adult pregnancy mice group (4.15±1,049). Test results showed
that there was differences of BDNF expression in the brain p = 0,000 (p< 0.05) with details, there were
differences in the cerebrum p = 0,015 and the cerebellum p = 0,000 between adolescent pregnancy mice
group and adult pregnancy mice group. Conclusion: BDNF expression in brain of Mus musculus newborn
from adolescent pregnancy lower than Mus musculus newborn from adult pregnancy.