The Relationship between Proinflammatory Cytokines, Trait Mindfulness, and Psychological Well-Being in Rheumatoid Arthritis

Authors

  • Krishan Tewatia
  • Dinesh N
  • Revathi P Shenoy
  • Shivashankara K N

DOI:

https://doi.org/10.37506/ijphrd.v13i1.17314

Keywords:

Proinflammatory cytokines, Psychological well-being, Rheumatoid arthritis, Trait mindfulness.

Abstract

Background: Rheumatoid arthritis(RA) is an autoimmune disease in which the body’s immune system
starts attacking its own cells especially, joints. Individuals with RA are 3 times more susceptible to
depression and anxiety. Mindfulness-based interventions have been found efficacious in decreasing
depressive symptoms and increasing psychological well-being(PWB) in this population, but the
relationship between trait mindfulness and PWB with proinflammatory cytokines implicated in RA has
not been explored to date.

Background: Rheumatoid arthritis(RA) is an autoimmune disease in which the body’s immune system
starts attacking its own cells especially, joints. Individuals with RA are 3 times more susceptible to
depression and anxiety. Mindfulness-based interventions have been found efficacious in decreasing
depressive symptoms and increasing psychological well-being(PWB) in this population, but the
relationship between trait mindfulness and PWB with proinflammatory cytokines implicated in RA has
not been explored to date.
Objective: This study aimed to understand the relationship between proinflammatory cytokines, trait
mindfulness, and psychological well-being in rheumatoid arthritis patients.
Method: The study consisted of a total of 16 individuals from the 45-75 years age group who have
been diagnosed with RA, taking treatment from Kasturba Medical College, Manipal. Proinflammatory
cytokines in saliva, IL-6 and TNF levels were measured using an ELISA kit, and scales were
administered to measure trait mindfulness, psychological well-being, and functioning. Descriptive
analysis was done to study the relationship between the variables.
Results: A significant increase in IL-6 levels were observed in the present study, while TNF- levels
were within normal limits. 50% of the participants reported severe impairment and 75% reported
depressive symptoms. These results provided evidence of a strong correlation between IL-6 levels
and depression. There was a strong positive correlation between trait mindfulness and psychological
well-being, . Trait mindfulness however had a moderately negative correlation with
depressive symptoms and disability. Moreover, the relationship between psychological well-being and
depressive symptoms and disability was not significant. The relationship between depressive symptoms
and disability was highly significant, 
Discussion and Conclusion: People with RA experience difficulty carrying out everyday tasks and
tend to suffer from depression. However, people who score high on Mindfulness and PWB experience
less depression and face less interference in their daily activities. Thus, interventions that promote
mindfulness practice and psychological well-being may prove to be effective in decreasing depressive
symptoms in RA patients as well as proinflammatory cytokines.

Author Biographies

Krishan Tewatia

M.Phil Clinical Psychology Trainee

Dinesh N

Associate Professor, Department of Clinical Psychology, Manipal
College of Health Professionals Manipal, MAHE, Manipal Karnataka

Revathi P Shenoy

Associate Professor Department of Biochemistry, Professor, Department of Medicine, Kasturba Medical College, Manipal

Shivashankara K N

MAHE, Manipal, Karnataka

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Published

2021-10-20

How to Cite

Krishan Tewatia, Dinesh N, Revathi P Shenoy, & Shivashankara K N. (2021). The Relationship between Proinflammatory Cytokines, Trait Mindfulness, and Psychological Well-Being in Rheumatoid Arthritis. Indian Journal of Public Health Research & Development, 13(1), 15–22. https://doi.org/10.37506/ijphrd.v13i1.17314