Chromogranin A - A New Panorama for Chronic Periodontitis and Psychosocial Stress
Keywords:Chromogranin A, Periodontitis, Psychological stress, Saliva, Plasma
Aims: The aim of this study is to determine, compare the Cg-A levels in saliva and plasma in periodontal
healthy, in patients with periodontal disease and correlate the same with the stress factor.
Materials and Methods: The study involved thirty subjects. There were categorized into three groups
with Group I (10 subjects with healthy periodontal status), Group II (10 subjects with mild to moderate
periodontitis) and Group III (10 subjects with severe periodontitis). The clinical parameters such as
plaque index, gingival bleeding index, clinical attachment loss and probing depth were recorded. Stress
was measured using Holme and Rahe stress rating scale. Blood and Saliva sample were collected and
Serum Plasma and Saliva CgA levels evaluated using ELISA. The data obtained from all the three
groups were analyzed using SPSS Systat 12 software. The mean variables between the three groups
were analysed using Kruskal Wallis test. The correlation between the variables and the stress scores was
assessed by Pearson’s correlation test.
Results: The results of the study showed significantly higher CgA levels in saliva and plasma of
patients with severe periodontitis compared with moderate periodontitis and healthy individuals (P <
0.05). There was also a positive correlation between stress scores and Salivary, Serum CgA levels and
all clinical parameters.
Conclusion: A significant association between elevated Cg A levels in saliva and plasma with
periodontal disease was present in our study. The results suggest that Salivary and Plasma Cg A can be
considered as a useful biomarker for evaluating etiopathogenesis of Periodontitis
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