Chemotactic Cytokine Receptor 5 Genetic Polymorphism in Diabetic Nephropathy of the Type 2 Diabetes Mellitus

Authors

  • Asri Lestarini
  • Anak Agung Sri Agung Aryastuti
  • I Wayan Putu Sutirta Yasa

DOI:

https://doi.org/10.37506/ijphrd.v13i1.17325

Keywords:

diabetic nephropathy, Chemotactic Cytokine Receptor 5, gene polymorphism

Abstract

Background and Aim: The inflammatory process can be involved in the pathophysiology of diabetic
nephropathy (DN). One of the cytokine receptors in the inflammatory process is Chemotactic Cytokine
Receptor 5 (CCR5), whose genetic variation can affect the incidence of DN in several populations in
the world. This study aims to determine the proportion of CCR5 gene polymorphisms with DN in type
2 diabetes mellitus patients in Bali.
Method: This study used a case-control design in 144 DNA samples of patients with type 2 diabetes
mellitus. They were examined for the polymorphisms of the CCR5 gene by PCR-RFLP and then
analyzed using Chi-Square statistical test. The p value <0.05 was significant.
Results: The proportion of males more than females in subjects with diabetic nephropathy (p = 0.000).
Duration of diabetes and systolic blood pressure were higher in subjects with diabetic nephropathy (p
= 0.002; p = 0.002) respectively. The polymorphisms of the CCR5 gene did not differ significantly in
subjects with and without diabetic nephropathy (p = 0.224).
Conclusions: Gender, systolic blood pressure and duration of diabetes were associated with diabetic
nephropathy, while CCR5 gene polymorphisms were not significantly associated with diabetic
nephropathy in type 2 diabetes mellitus patients in Bali.

Author Biographies

Asri Lestarini

Department of Biochemistry, Faculty of Medicine and Health Sciences, Warmadewa University, Jl.
Terompong No. 24 Denpasar, Bali, Indonesia 80235

Anak Agung Sri Agung Aryastuti

Department of Pharmacology, Faculty of Medicine and
Health Sciences, Warmadewa University, Jl. Terompong No. 24 Denpasar, Bali, Indonesia 80235

I Wayan Putu Sutirta Yasa

Doctoral Program, Faculty of Medicine, Udayana University, Jl. PB Sudirman, Denpasar, Indonesia-80234

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Published

2021-10-20

How to Cite

Asri Lestarini, Anak Agung Sri Agung Aryastuti, & I Wayan Putu Sutirta Yasa. (2021). Chemotactic Cytokine Receptor 5 Genetic Polymorphism in Diabetic Nephropathy of the Type 2 Diabetes Mellitus. Indian Journal of Public Health Research & Development, 13(1), 83–90. https://doi.org/10.37506/ijphrd.v13i1.17325