Association of Lipid Profile Ratios to Diabetes Mellitus and Hypertension in an Indian Population
DOI:
https://doi.org/10.37506/ijphrd.v13i2.17888Keywords:
Triglycerides, HDL-C, Type 2 diabetes, Hypertension, Odd ratio, ROC curveAbstract
Objective: Two lipid ratios (i.e. triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)
and HDL-C/total cholesterol (TC)) along with other lipid levels have been considered as important
measures of lipid profile and risk for developing coronary disease and type 2 diabetes (T2D). This paper
investigated independent association between index of lipid measures with T2D and hypertension in a
study of Indian population.
Methods: In this prospective study, 162 patients were selected and recorded their socio-economic and
physical characteristics. Each participant was evaluated for lipid levels i.e. TC, TG, HDL-C, low-density
lipoprotein cholesterol (LDL-C) and examined for T2D and hypertension. Multiple logistic regression
was conducted to find odd ratios (ORs) between lipid measures and ratios with T2D and hypertension.
Measures of each lipid and ratio were stratified into quintiles of the distribution and ORs with 95% CIs
were estimated for each quintile with lowest quintile as reference. Receiver operating characteristic
(ROC) curve was used to discriminate individuals with T2D or hypertension from individuals without
T2D or hypertension.
Results: Patients with T2D and hypertension had higher TG/HDL-C and lower HDL-C/TC
(p-value<0.01). T2D and hypertension shared an independent positive correlation with TC, LDL-C,
TG, HDL-C/TC and TG/HDL-C. Significant increasing trends in OR for T2D and hypertension were
seen in TG/HDL-C and TG (p-value<0.01). Comparing areas of ROC curves, TG/HDL-C played a
more superior role in discriminating between participants with and without T2D, hypertension.
Conclusions: TG/HDL-C is strongly associated with T2D and hypertension and is a superior predictor
to other lipid measures as a risk marker in this population.