Eosinophilia Induced Acute Interstitial Nephritis: A Case Report

Abstract

Introduction: This report presents the case of a patient with tubulointerstitial nephritis (ATIN) due to
Eosinophilia, situation that has not been reported in India.
Case Presentation: A male patient with a history of pulmonary tuberculosis treated with ATT developed
acute kidney injury. On admission, no evidence of abnormalities or history to explain the injury was
found, but he did present tubular acidosis and associated Fanconi syndrome. The kidney injury was
temporarily consistent with ATT use, and a kidney biopsy confirmed ATIN. The drug was suspended,
resulting in improved kidney function.
Discussion: ATIN as a side effect of rifampin is a scarcely reported disease. The risk of developing this
condition should be considered when starting and restarting treatments with this medication.
Conclusion: ATIN is one of the side effects of tuberculosis treatment. Albeit rare, it should be considered
when starting tuberculosis medications.