Clinicohematological profile of patients with Pancytopenia

Abstract

Background: Pancytopenia is common and important clinico-hematological problem encountered in our daily clinical
practice. The pattern of diseases leading to Pancytopenia is expected to varying in different population groups with
difference in age pattern, nutritional status, and prevalence of infective disorders. The severity of pancytopenia and the
underlying pathology determine the management and prognosis
Objectives: To study the etiology and clinic-hematological profile in patients of peripheral blood pancytopenia
Materials and Methods: This was a prospective study conducted at Uttar Pradesh University of medical sciences, Saifai,
Etawah during the period of January 2019 to June 2021.
Results: A total of 202 patients (108 males and 94 females) were diagnosed to have pancytopenia. Most of the patients
presented with generalized weakness and fever. The commonest physical finding was pallor, followed by spleenomegaly.
The various causes of pancytopenia included infections(n=138), megaloblastic anaemia (MA)(n=44), drugs, aplastic
anaemia and subleukaemic leukaemia. We found a significant association between megaloblastic anaemia and
pancytopenia
Conclusion: The present study concluded that infection and megaloblastic anaemia are the most common cause of
pancytopenia.