Maternal Death Model Decreases the Expression of BDNF in Rattus Norvegicus Newborns’ Cerebrum and Cerebellum

Authors

  • Duhita Dyah Apsari1, Hermanto Tri Joewono2, Widjiati3

DOI:

https://doi.org/10.37506/ijphrd.v11i3.1828

Keywords:

BDNF expression, separation from mother, maternal death model

Abstract

Context: Maternal death occured in pregnancy period up to 42 days after giving birth. Maternal death
could cause early life stress in newborns which activated HPA axis and glucocorticoid secretion as stress
hormone marker. The developing brain was very sensitive to the initial exposure to stressors that would
affected the Brain Derived Neurotrophic Factor (BDNF) expression, which was one of the most important
endogenous mediators of stress responses in the brain. This study aimed to analyze BDNF expression in
the cerebrum and cerebellum of Rattus norvegicus newborn with maternal death model. The control group
(K1) consisted of newborns Rattus norvegicus which were not separated from the mother until 3 days old
and the treatment group (K2) is maternal death model consisted of newborns Rattus norvegicus which were
separated immediately from the mother after birth until 3 days old and fed with animal milk as a substitute
nutrient. After 3 days treatments, 3 newborns with heaviest, medium, and lowest weights were taken from
each mother to sacrifice. The BDNF expression examination was carried out on cerebrum and cerebellum
by imunohistochemical method. The results showed that the mean BDNF expression in the cerebrum and
cerebellum of 3 days old Rattus norvegicus with maternal death model which separated from the mother
were lower than the mean BDNF expression of control group though there were no significant different
based on statistical analysis.

Author Biography

  • Duhita Dyah Apsari1, Hermanto Tri Joewono2, Widjiati3

    1Postgraduate Student of Reproductive Health Sciences, Faculty of Medicine, Airlangga University, Surabaya,
    Indonesia, 2Department of Obstetrics and Gynecology, Airlangga University, Surabaya, Indonesia, 3Prof.,
    Department of Embryology, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia

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Published

2020-03-26

How to Cite

Maternal Death Model Decreases the Expression of BDNF in Rattus Norvegicus Newborns’ Cerebrum and Cerebellum. (2020). Indian Journal of Public Health Research & Development, 11(3), 1484-1489. https://doi.org/10.37506/ijphrd.v11i3.1828