Functional Features of the Endothelium in Conditions of Dysfunction of Cardio-Vascular System
DOI:
https://doi.org/10.37506/ijphrd.v11i3.1850Keywords:
Cardiovascular system, dysfunction, endothelium, coronary heart disease, heart rhythm disturbances, diabetes mellitus.Abstract
Context: Of great interest to modern researchers are processes that affect vascular tone in patients with
coronary heart disease. It is known that in the atherosclerotic process in the coronary vessels there is a
varying degree of severity of endothelial dysfunction with the dominance of vasoconstrictor mechanisms.
The results of the examination of 63 patients with coronary heart disease and type II diabetes mellitus
with concomitant arrhythmias and 20 practically healthy individuals aged 51 to 62 years are presented. All
examined were divided into 6 groups. It was shown that the development of cardiac arrhythmias in patients
with coronary heart disease with concomitant type II diabetes mellitus is accompanied by an increase in the
level of endothelin-1, which reflects impaired endothelial function. Along with this, the activation of the
renin-angiotensin-aldosterone system due to an increase in the level of angiotensin II, the activation of the
sympathoadrenal system with a decrease in the level of cyclic guanosine monophosphate form the conditions
for persistent cardiac arrhythmias and require timely intervention to eliminate neurohumoral disorders.
